Study reveals epigenetic mechanisms regulating ILC2 memory and asthma recurrence

Researchers have revealed a novel mechanism by which the chromatin remodeler brahma-related gene 1 (Brg1) regulates Group 2 innate lymphoid cells (ILC2s) in allergic lung inflammation. Brg1 exacerbates allergic lung inflammation by regulating the chromatin status of ILC2s, enhancing their aerobic glycolytic metabolism, and consequently promoting the expansion of effector ILC2s (ILC2eff) and memory ILC2s (ILC2mem…